Does Second Impact Syndrome Exist?

It has often been reported that when a person suffers a second concussion (mild traumatic brain injury) before recovery from the first concussion takes place, that catastrophic brain swelling and death can result. This has been alleged to occur based on anecdotal information and when it happens (usually in young male athletes) it is referred to as “second impact syndrome” (SIS). SIS is often reported as a factual entity in the media and in the medical literature.


However, when one assess the evidence-based data for whether SIS truly exists, we are left with far more questions than answers. As Dr. Paul McCrory and colleagues (2012) put it, “The phenomenon of the second impact syndrome (SIS) continues to appear in the medical literature in spite of the lack of systemic evidence for its existence.” While McCrory's work is accessible through medical libraries, I have never seen in discussed in mainstream media coverage of SIS. Thus, a brief summary is presented below for ease of access for those who are interested.

Dr. McCrory has been studying SIS with evidence-based methods for over a decade. In fact, the seminal empirical study on this topic was performed by McCrory and Berkovic (1998). This was followed by a classic 2001 paper by McCrory entitled “Does Second Impact Syndrome Exist?,” which is the basis of the title of this blog entry.

In the 2001 paper, McCrory noted that 35 cases from the National Center for Catastrophic Sport Injury (NCCSI)  were cited as probable cases of SIS but not published in scientific journals due to lack of confirmatory details. McCrory referenced his 1998 study, in which he and Berkovic independently applied four basic criteria to 17 published SIS cases to determine how many would result in a diagnosis of definite SIS. Those criteria were as follows:

1) Medical review after a witnessed first impact.

2) Documentation of ongoing symptoms following the first impact up to the time of the second impact.

3) Witnessed second head impact with a subsequent rapid cerebral (brain) deterioration.

4) Neuropathological or neuroimaging evidence of cerebral swelling without significant intracranial hematoma (bleeding) or other cause for edema (swelling).

Not a single patient met all four criteria. Thus, there was not a single confirmed case of definite SIS in any of the cases reviewed despite the fact that all of them had been previously described or quoted as examples of SIS. Further analysis of the study revealed even more interesting details. For example, in 11 of 17 published cases, there was no evidence that a second impact actually occurred despite the fact that four of those cases had been heralded as “classic” examples of SIS in the literature. They also found that most of the evidence used to support a first impact was based on teammate recall (subjective evidence) rather than video tape (objective evidence).

Rather than merely accepting that the teammate recall was correct, McCrory and Berkovic performed a study of 102 football players to assess the reliability of their recall for concussive injuries sustained by their teammates. Their recall was compared to video-taped reviews and recall of the injured player. McCrory and Berkovic found that the teammates significantly over-reported the presence of initial impacts. In other words, they tended to report that a concussion occurred when objective evidence indicated otherwise. In only 11% of cases was there immediate medical documentation after the reported initial impact. Seventy-one percent of the cases were described as not meeting SIS criteria, whereas five of the 17 cases (29%) met three of the four criteria, with neither having a medical review after a witnessed first impact. These cases were described as probable (but not definite) SIS.

In McCrory’s 2001 article, he questioned why it is that SIS only tends to be reported in the United States despite the fact that similar or greater concussion rates occur in competitive sports throughout the world. To research this issue further, McCrory (who is from Australia) analyzed all deaths due to Australian football from 1968-1999. In these 32, there were 25 player deaths. Of these, nine were due to a neurological trauma and the others were due to non-neurological factors. Of the nine traumatic brain injury deaths, how many met criteria for SIS? None. No cases of SIS despite the fact that McCrory notes that the concussion risk in Australian football is about eight times that of American football. The risk of death from brain injury in this sample was 1 in 30 million player games. McCrory also questioned why there are not more cases of SIS in boxing compared to other sports due to the frequent concussive head trauma experienced in most fights.

McCrory also stated in his 2001 paper was that the published 1984 case by Saunders and Harbaugh that first used the term “second impact” to describe the death of a 19-year-old college football player actually did not have a described second impact. It is true that the wording used by Sanders and Harbuagh did not describe the second impact but it is also true that their wording does not preclude that some type of second impact to the head occurred. Specifically, all that they say about the second impact is as follows, “Despite accounts of no unusual head trauma, he walked from the field and collapsed.” The key word is “unusual.” This technically does not mean that no head trauma occurred but it means that there was no head trauma that anyone observed that was out of the ordinary. One could argue, however, that a head injury significant enough to cause a concussion would be considered unusual.
  
McCrory noted that belief in SIS has reached “almost mythical proportions” and that the term “second impact syndrome” is misleading. He suggested that SIS be replaced with the term “diffuse cerebral swelling” (a finding that was present in most of the cases he reviewed), and that this extremely rare condition is caused by a single brain injury (emphasis mine). I strongly agree with him. Another point I agree with him is the following conclusion from his 2001 paper:

“Most cases of traumatic cerebral swelling, whether associated with a structural brain injury or not, have no prior evidence of head injury with ongoing symptoms that would support the concept of second impact syndrome as defined in the literature. In those cases that are presumed to represent SIS, the evidence that a prior head injury is a risk factor for this pathophysiological entity is not compelling.”
 
One of the other points McCrory makes in his 2001 article relates to when the initial clinical presentation does not match the objective severity of the injury because of a gradual progressive decline as opposed to an immediate and rapid one. He noted that scientists have commented on this phenomenon dating back to 1891 and that the condition is now commonly referred to as “talk and die syndrome” because the person is initially conversant but then gradually and fatally deteriorates (or comes close to fatally deteriorating). He noted that this delayed response occurs in about 15% of all cases of “severe” head trauma and is caused by an intracranial hematoma (bleed) in 75% of those cases. Sometimes, the bleed is present when the patient’s brain is initially scanned but sometimes the bleed is not observable until after a delay.

It has been over 10 years since McCrory published his 2001 paper and so I contacted him to determine if his views on SIS had changed. McCrory’s response to me on August 11, 2010 was as follows and I am reporting it for the first time here (with permission):

“My conclusions on 'SIS' are unchanged. I have continued to track the literature and claims made on this topic and while I am happy to accept that perhaps someone may be able to satisfy the criteria (as per the original article) and really have the condition, I am yet to see it.  It is worth observing that the US is the only place on the planet where SIS is actually discussed as an entity. Most other countries have moved on from this viewpoint years ago.”

Yet, in the U.S., the most recent (June 2012) Guidelines for Concussion Management in the School Setting, published by the New York State Education Department (SED), states as a fact that "Additionally, children and adolescents are at increased risk of protracted recovery and severe, potential permanent disability (e.g. early dementia also known as chronic traumatic encephalopathy), or even death if they sustain another concussion before fully recovering from the first concussion."  It's a classic example of mythology prevailing over data. As a disclaimer, I served as a formal advisor to SED regarding this document and have asked to be removed due to statements such as these (and others that I strongly oppose) making their way into the final document despite presenting the data described above. There is not even mention of at least a controversy being present about this issue.

McCrory and colleagues (2012) and Randolph and Kirkwood (2009) point out that delayed cerebral swelling does not require multiple injuries to occur, is most likely caused by a genetic susceptibility, and is extremely rare. For example, Randolph and Kirkwood cited statistical data showing that the rarity of this outcome in 10 years of American football (1997-2006) was 1 in 1.8 million players. Despite this rarity, millions of dollars are being spent on baseline cognitive testing, largely with the hopes of preventing this outcome. People are scared by the media reports and schools do not want to be held liable. Hence, the need to want to “do something” and testing fits the bill. The problem is that the bill (using conservative estimates), according to Randolph and Kirkwood, amounts to 36 million dollars over 10 football seasons to try and prevent a 1 in 1.8 million person outcome.

McCrory and I agree that it makes sense to hold patients out of play after they have suffered a concussion (consistent with the 2009 Zurich consensus guidelines on return to play after concussion; which were authored by McCrory) because it reduces that chances of further injury to the brain and/or other parts of the body (due to slower reaction time) but not because it is going to reduce the risk of post-traumatic cerebral swelling. I also agree with Randolph and Kirkwood that the best way to manage patients who suffer head trauma during sports (and to try and reduce a catastrophic outcome) is via close observation to detect a neurological decline and to immediately initiate medical/neurosurgical intervention if such a change is detected.

Related articles:

 1. Junior Seau Did Not Suffer 1500 Concussions
 2. CTE and Suicide Link is Premature Speculation

References:

McCrory PR, Berkovic SF. Second impact syndrome. Neurology; 1998;50(3):677-683.

McCrory P. Does second impact syndrome exist? Clinical Journal of Sport Medicine; 2001;11(3):144-149.

McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on concussion in sport - the Third International Conference on Concussion in Sport held in Zurich, 2008. Phys Sportsmed. 2009;37(2):141-159.

McCrory PR, Davis, G, Makdissi, M. Second Impact Syndrome or Cerebral Swelling after Sporting Head Injury. Current Sports Medicine Reports; 2012; 11(1),21-3.

Randolph, C. & Kirkwood, M. What are the real risks of sport-related concussion, and are they modifiable? Journal of the International Neuropsychological Society; 2009;15, 512–520 .

Saunders RL, Harbaugh RE. The second impact in catastrophic contact-sports head trauma. JAMA; 1984; 252(4):538-9.

Why You Need to Be Cautious When Shopping for Homeopathic Medications

I’m all for natural (homeopathic) treatment of health care problems if there is scientific evidence that it is effective.  As in the old days, people still rely on word of mouth recommendations from friends and family, casual review of non-scientific literature, and the advice of someone selling homeopathic products  to decide what medications to take to treat their ailments. These days, people have the added option of searching for such medication on the internet. No prescription is needed and the consumer proceeds at his/her own risk since the Food and Drug Administration does  not require that homeopathic medications undergo testing for safety and effectiveness.  

Many people are not aware of this and simply assume that since the medications are contained in a fancy looking bottle with scientific words, have stated indications for use, and/ or are sold on a website that looks legitimate, that they are safe and effective. While ineffective homeopathic medications may not directly cause harm, they can indirectly cause harm if the person fails substitutes an unproven treatment with a scientifically proven treatment. In some cases, this choice can mean the difference between life and death. A good example is How Fruits and Vegetables Killed Steve Jobs.

In perusing the internet tonight, I can across an advertisement for  oxydendrum arboreum (pictured above), also known as the sourwood or sorrel tree.  The ad states that it Is used for the following: “A remedy for dropsy - ascites and anasarca. Urine suppressed. Deranged portal circulation. Prostatic enlargement. Vesical calculi. Irritation of neck of bladder. Great difficulty of breathing. Tincture. Compare: Cerefolius (dropsy, Bright’s disease, cystitis).”

Let’s go through some of these terms. If you are not in the medical field, you may not realize that although this sounds fancy, that dropsy is an outdated term for edema or swelling. Ascities means fluid build-up in the space between layers that line the belly. Anasarca is extreme generalized edema. Suppression of urine output is obvious, as is difficulty breathing, prostate enlargement, and neck/bladder irritation. Vesical calculi is another terms for a bladder stone. Tincture refers to an herbal tincture, which is an alcoholic extraction of plant material by combining it with a liquid, typically alcohol. In other words, the medication is available in liquid form. It was also available in tablet form. On the last line, the ad compares the medication to another homeopathic treatment (Cerefolius) used to treat dropsy, cystitis (bladder inflammation), and Bright’s disease. Bright’s disease is an obsolete term used to describe acute or chronic kidney inflammation.

The use of obsolete words such as dropsy and Bright’s disease on a modern medical ad made me suspicious, so I did some more research and found this old advertisement from 1908:

Lo and behold what do we see?  Terms such as Bright’s disease, dropsical effusions (a reference to dropsy), anasarca, ascites, and edema as conditions that can be treated by a medication known as oxydendrine. Oxydendrine’s first ingredient is listed as oxydendrum, the plant being sold above on the internet today. Oxydendrine was the trade name for a medication that combined oxydendrum with other plant treatments including iris, sambucus,  and scilla (squill).  In 1908, it was being recommended that when used to treat dropsy due to heart disease, that the medication be taken with each meal and at bed time. For most people that is four times a day, which is a lot of pills. In fact, in severe cases, up to 8 pills a day were suggested. More pills equals more money. 

It does not seem that Oxydendrine was around long based on my own research into the topic, although I am happy to be provided any information to the contrary on that.  I can confirm that it was in use between 1907 and 1908. There is no scientific literature available in PubMed (repository of peer reviewed scientific research studies) that support the use of Oxydendrine or the primary ingredient, oxydendrum, for any medical treatments.  It seems like it was yet another type of patent medication such as Pink Pills for Pale People, which purported to treat various ailments without proof of safety or effectiveness.

 It also seems that information about Oxydendrine was taken from medical ads from over 100 years ago and used as the basis for a modern ad for a homeopathic treatment on the internet. While oxydendrum may indeed have some unknown medical properties, buyers beware when purchasing this substance or others that you have not properly vetted scientifically. If you need suggestions on how to do that, see my Five Ways for Evaluating Suspicious Medical Treatment Claims.

Cannibal Icepick Killer Luka Magnotta was Not Born Evil

While I may be wrong, I have never bought into the notion that people are born evil. It seems like a far too simplistic explanation and can serve as a way to conveniently ignore the ways in which negative life experiences (e.g., abuse, neglect, and poor parenting) combined with a lack of positive coping resources and other factors, can lead to depression, anxiety, low self-esteem, building to anger, rage, revenge fantasies, and abusive tendencies. For sure, people are born with biological temperament, but this temperament interacts with life experiences to shape who we are as individuals.

This brings me to the disturbing case of Luka Rocco Magnotta, who was widely known for videos he posted on Youtube involving the torturing and killing of kittens, followed by bestiality. More recently, he has recently been arrested for videotaping himself murdering a college student, Jun Lin, with an icepick, dismembering him, cannibalizing the corpse, engaging in sexual acts with it, posting the video on the internet, and mailing the body parts throughout Canada. Was he really born to do this? Nothing could have stopped it? He could have had no other type of life? I’m not buying it.

While new information is emerging daily, we know that Magnotta was born as Eric Clinton Kirk Newman on 7/24/82 in Scarborough, Ontario, to Don Newman and Anna Yourkin. At some point in childhood, it is known that he went to live with his grandmother in Lindsay, Ontario. While I have never met him, and I am not trained in psychological profiling, as a psychologist, my informal perspective on the matter is that the following played key roles in leading to where we are today. This perspective is based on media reports and is contingent upon the accuracy of the information in those reports.

1. Traumatic childhood: While details from his early childhood are very hard to come by, it has been reported (by one of his own family members) that his family life was very dysfunctional. His parents did not remain together. Based on comments he has made on the internet, he described a “horrible” childhood and did not feel loved by his family. He has been said to report on the internet that he had been sexually abused multiple times. Whether that is true or not is unknown at this time, but I am inclined to believe it given what we know about his sexually abusive behavior. While everyone responds to abuse differently,  some people hold in significant anger and seek ways to reverse roles, regain a sense of lost power,  and become the abuser against a helpless victim. This was popularized on the popular TV show, The Shield, when police captain David Aceveda responded to male rape by being abusive to women and eventually having the offender killed. As described in a prior blog post, animal abuse is often the precipitant to human abuse, and Magnotta engaged in numerous such actions against kittens and possibly other animals as well.

2. Not feeling loved: There are many victims of child abuse who go on to live successful and productive lives, which is aided by having a positive support system in place. For Magnotta, however, that does not appear to be the case. His father was reportedly not a significant presence in his life (he claims not to have even known him), his mother does not appear to have been around him much (and when she was they reportedly did not get along), and he was reportedly raised by a domineering grandmother. So now we have alleged abuse combined with what appears to be a lack of emotional support and further experiences of being under aversive control. Not a good combination. His grandmother has been described “…as a domineering personality who would beat up people with submissive personalities and get them to do what she wants.”  He was been quoted as saying about himself on the internet that “All he wanted was love.”

3.  Low self-esteem and narcissism:  A past filled with trauma and emotional neglect can easily lead to low self-esteem. One maladaptive defense mechanism for this is the development of narcissistic personality disorder, the essential features of which is a pervasive pattern of grandiosity, need for admiration, and lack of empathy that begins by early adulthood and is present in a variety of contexts. An ex-girlfriend described him as emotionally cold. He clearly was obsessed with his self-image, which he admitted during an audition for a plastic surgery show. He posted a large volume of model shots of himself online (just do a Google Image search to see this) which often show him in provocative poses,  fancy cars, and prominently worn designer clothes, all of which are designed to convey self-importance. He had more than 70 Facebook accounts about himself whereas the average person has one. He is known to have created numerous fake usernames on internet message boards in which he wrote about himself, spread rumors to create an additional sense of self-importance, and then denied them to draw further attention to himself. Despite all of his attempts at success, he was a continued failure, including his botched attempts to become a porn star and reality TV show contestant. These failures may have fueled his rage against society. Ironically, as police predicted, his narcissism led to his arrest when he was found in an internet cafe reading stories about himself.

4. Immersion in fantasy life:  While most people are able to differentiate fantasy from reality, some people become obsessed with fictional characters or develop fantasy relationships with non-fictional individuals. For example, he was known to be obsessed with James Dean, the famous actor best known for portraying a troubled teen with a dysfunctional family defying society in Rebel Without a Cause. Dean and Magnotta bear somewhat of a physical resemblance, which helps make the fantasy immersion more real. He became obsessed with plastic surgery, partly to help him look more like Dean, and he was known to pose like Dean in various photos. He spread rumors that he dated Karla Homolka, a famous Candia murderer who videotaped rape and murders she was involved with. He was known to use the name, Kirk Tramell, as an alias, a likely take on Catherine Tramell in the movie, Basic Instinct, who kills a lover with an icepick. His name change to Luka Rocco Magnotta on 8/12/06 reflects a combination of low self-esteem (not liking his original identity) and appears to reflect his latching on to fantasy characters. It is widely believed that he chose the name Magnotta after the character Vince Magnotta from a video game called Ripper. The character is a serial killer who butchers his victims. It is unclear where his cannibalistic urges came from but cannibal themes are actually quite prevalent in fiction and non-fiction, that he likely glommed on to one or more of these characters/individuals as a morbid curiosity.

In conclusion, I do not believe that Luka Magnotta was born evil. He may have been born with a negative temperament, but his crimes were shaped by negative events in his life, a lack of pro-social coping resources, an increasing sense of alienation, emotional pathology, revenge and power fantasies, immersion in fantasy life, and an obsession to draw attention to himself. Lastly, this article should not be taken as excusing his criminal actions, but as a way to explain his behaviors from a psychological perspective. For the record, I find his behaviors reprehensible, abhorrent, and believe he should be prosecuted and punished to the fullest extent of the law.

Related blog entries:
A Psychological profile of Wade Michael Page: The Sikh Shooter
A Psychological Profile of James Holmes: The Joker Killer
A Psychological Profile of Chardon School Shooter, T.J. Lane

Stopping Pet Abuse Helps Stop Cannibal Killers and Other Violent Criminals

There is a very good reason why society should have zero tolerance for the abuse of animals and children: because they are the essence of innocence, uncorrupted by society. However, the innocence that most of society cherishes in animals and children is exactly what makes them so alluring to sociopaths. They enjoy the power they have over a life that is defenseless and enjoy using that power to corrupt it. Animal abuse can involve killing, torturing, neglect and/or defiling the body of animal.

For many people who go on to commit unspeakable crimes against humans, non-human animals usually serve as the first targets. There are many examples of this. Jeffrey Dahmer, who became a human cannibal as an adult and experimented on his victims, dissected dead animals and impaled a dog’s head on a stake. Alleged murderer, Luka Rocco Magnotta, who allegedly stabbed a man repeatedly with an ice pick, dismembered him, and ate part of his body, began his criminal acts with animals, feeding a kitten to a python and also killing two kittens by placing them in a plastic bag, sucking the air out with a vacuum, dismembering them, and performing sexual acts with their body parts.

I can go on and on with many other revolting examples, but the two examples above make the point. While very difficult to hear and even write about, society needs to make the capture, prosecution, and sentencing of animal abusers a much higher priority. For example, it is amazing to me that Magnotta was never arrested by law enforcement for his kitten murders despite widespread outrage by many on the internet to identify and stop him. If he had been arrested and prosecuted for kitten murders, then the person he killed would probably still be alive today provided a meaningful sentence was implemented. 

Fortunately, most states have felony provisions for animal abuse, but it is unacceptable that three do not: Idaho, North Dakota, and South Dakota. Across all states, the average maximum jail time for animal abuse is 47.2 months (about 4 years). The states that take this issue the most seriously are Alabama and Louisiana (10 year maximum sentences) and the state with the shortest sentence is North Carolina (6 months maximum sentence). The average fine for animal abuse across the U.S. is $24,420. However, that average is significantly skewed by Colorado imposing a maximum fine at $500,000, followed by Arizona at $150,000 and Oregon at $100,000. The fines from most states are actually $5,000 or less. The lowest maximum fine is $1,000, which occurs in North Carolina, Arkansas, Rhode Island, and South Dakota. One state (Tennessee) does not appear to have a fine.

Only 14 states have laws that allow for a temporary or permanent ban on animal ownership as part of sentencing. That means 36 do not. Only 7 states have laws that allow allows for animals to be included in protective orders (known as pet protective orders). That means 43 do not. Thirty-two states include mandated counseling for animal abusers. That means 28 do not.

There are a few things worth noting from the existing penalties for animal abuse, which is courtesy of Pet-Abuse.com. First, in many states, it costs more to purchase a pure breed animal than it costs to torture and kill it. That should never be the case and should be changed. Second, all states should have mandated counseling for animal abusers, allow for a permanent ban on pet ownership (after you abuse a pet you should not get a second chance), and should allow for pet protective orders. Third, the states of South Dakota and North Carolina appear to take animal abuse the least seriously since the former does not include animal abuse as a felony and has one of the lowest fines while the latter has the shortest maximum jail sentences and one of the lowest fines.

Of course, people need to use common sense when it comes to what constitutes a crime in the death of animals, since there are people who have licenses to hunt and fish, companies that slaughter animals for food, and who among us has not swatted a fly in the house to prevent the spread of germs? All of these instances, however, are vastly different from somebody who kills an animal for the express purposes of gaining pleasure from watching it suffer and/or die. These are the people who need to be identified, prosecuted, and stopped, not only in the pursuit of justice, but also to prevent hard to human beings.

Children need to be taught from early on to respect life and to follow the Golden Rule. This means no killing of animals, including insects, purely for pleasure or entertainment. This teaches empathy, which is something lacking in many people who go on to become violent criminals.

If you want to see just how common animal abuse is, just do a zipcode search in the national searchable database at Pet-Abuse.com to see the shocking results near you. Those very people may go on to abduct and kill one of your family members or someone in your community. Visit Pet-Abuse.com to find out more about how you can help. 

Why All of the Recent Human Cannibalism?

Warning: This blog entry contains information that is graphic and disturbing. Do not read further if you are not so inclined. Ta Ta.

It began on Saturday, 5/26/12. The nation was shocked to hear that 31-year-old Rudy Eugene, a resident of Ft. Lauderdale, ran naked down the Miami Causeway, came across a 65-year-old homeless man (Ronald Poppo) lying innocently in the shade, pummeled him in broad daylight, and devoured most of his face.

I had actually recently posted a blog entry about my personal observation of an obese, naked, mentally ill man rolling around Ft. Lauderdale Beach for years, but the Rudy Eugene story was something well beyond that. There are news reports that Eugene had a history of aggression, paranoia, religious pre-occupation, and poverty. Given his age, it is possible that he may have had a mental illness such as schizophrenia, but even if this is true, cannibalism is not common in schizophrenia. It is unclear if Eugene was intoxicated at the time and there has been much speculation that he showed tell-tale signs of delirium and aggression on that day due to ingestion of bath salt stimulants that he may have ingested at a Miami concert the night before.

Then on 5/30/11, it was revealed that a 29-year-old gay porn actor named Luka Rocco Magnotta (real name Eric Clinton Newman), who was known for killing kittens and posting the videos online, shipped human body parts (i.e., foot, hand) to political parties in Canada. I joked that night that I was scared to see what tomorrow’s news will bring. Indeed, on 5/31/12, it was revealed that Magnotta videotaped himself killing the victim, eating parts of him, and then releasing the video on the internet. This was after his animal abuse exploits went unaccounted for. And if that wasn’t enough, a 21-year-old Maryland college student named Alexander Kinyua was arrested the same day for killing his 37-year-old housemate, cutting him up, eating his heart, and part of his brains.

That’s three human cannibal stories in less than one week, which is extremely bizarre.
As a scientist who studies the causes of human behavior, I wanted an explanation as to why this was happening and why someone would ever decide to eat another human besides starvation in extreme conditions. Below is a basic summary of what I have found, thought about, and hypothesized, to understand this issue more but I welcome your comments as well because I sure do not have all the answers.

To begin with, the word cannibal comes from the fact that Christopher Columbus wrote about ferocious people from the Carribean islands and parts of South America, known as the Caniba, who ate people. Some anthropologists believe that cannibalism was very common in pre-historic times. There is even a story of cannibalism in the Bible (2 Kings: 25-30). As a neuropsychologist, I am also familiar with the incurable neurodegenerative prion disease known as kuru, which was transmitted when members of the Fore tribe of Papua New Guinea consumed the dead.

There have been many stories throughout history of cannibalism due to necessity from famine. Many may be surprised to know that this happened among U.S. colonists, who dug up corpses for food. One colonist even killed, salted, and ate his pregnant wife. Many are more familiar with the cannibalism among the Donner party, a U.S. settlement group in the mid-1800s. Cannibalism occurred all over the world, such as in Nazi concentration camps, Japanese troops in WWII, China and North Korea (due to famine), and many others. 

Then there are cannibal stories popularized in our culture, such as the hag in Hansel and Gretel who tries to cook and eat little children. We are told of Count Dracula, who didn’t actually eat people, but bit their necks and sucked their blood. The Dracula craze has never died off and is popularized in modern times by the Twilight book and movie series. Zombies have also been very popular as popularized the Living Dead series and their quest for eating human flesh. Then there is the story of Leatherface, in the Texas Chainsaw Massacre, who was a cannibal living amongst a family of cannibals. Leatherface took things one step further and wore the skin of his victims. Perhaps the most famous modern fictional cannibal is Hannibal Lecter, who was famous for eating his victim’s faces (sound familiar?).

Many people perform a very limited form of self-cannibalism, such as biting their fingernails and toenails and eating them although some dispute that this is true self-cannibalism. Some people eat their own skin after it has peeled off from a bad sunburn. Some people also eat their own hair, which is known as trichophagia. Some people eat their own scabs. Some animals (e.g. goats) are known to engage in self-cannibalism as well such as eating the placenta of their young but this is for nutritional benefit. The short-tailed cricket is known to eat its own wings. The North American rat snake has been known to try to consume its own body.

Back to humans, most people all familiar with the cannibalistic crimes of Jeffrey Dahmer. One of the most disturbing cases is that of Albert Fish, who cannibalized young children and tormented parents by sending them notes vividly describing his crimes. Andrein Chikatilo used cannibalism as a way to gratify his sexual needs, in an extreme extension of Count Dracula. Just a few years ago (2008), Tim McLean was savagely decapitated on a Greyhound bus by 40-year-old Vince Weiguang Li, who then proceeded to eat parts of the body.

This year, a German researcher (Hamalainen, 2012) reported the first case of a non-human primate (gray mouse lemur) cannibalizing an adult member of the same species. The body cavity was torn open and the inner organs eaten. The skull had been broken and the brains were consumed. The spinal cord was being devoured as well. It is unknown if the cannibal lemur had killed its victim or if it was scavenging. The authors concluded that “Cannibalism may confer immediate nutritional and energetic benefits to the cannibal and therefore might have adaptive value at the individual level.” Previously, non-human primates had only been known to cannibalize the young. Some insects (e.g., praying mantis), fish, amphibians, and birds have been known to cannibalize adults members of the same species.

Overall, if you think about it, cannibalism has been practiced all over the world and throughout history, sometimes due to famine, sometimes due to crime, and sometimes due to mental illness. It occurs in humans, insects, and various other non-human animals including primates. It is popularized in our culture through scary stories told to children and horror movies designed to scare adults. It is also relatively common for people to eat parts of their own skin (e.g., nails, hair, peeled skin) and scabs. My theory is that what  happened in the Rudy Eugene case is that someone with a probable prior mental illnesses and/or certain form of drug intoxication caused him to become disinhibited and regress to a very primitive evolutionary state. Whether this is what happened in the other two cases is less clear given that not enough information available. Why there have been three cases in less than one week is also unclear but one has to wonder if there is a copycat crime element to this in some people who are already seriously mentally ill.

References:

Hamalainen, A. (2012). A Case of Adult Cannibalism in the Gray Mouse Lemur, Microcebus murinus. American Journal of Primatology 00:1–5 (2012).
Wikipedia cannibalism page
Wikipedia self-cannibalism page

Pink Pills for Pale People

In my ongoing documentation of medical claims and treatments that are overly promoted despite not having scientific evidence to support that they work as advertised, today’s blog entry turns its focus on Dr. Williams’ Pink Pills for Pale People. As you can see from the ad below (click to enlarge), this medication was not only said to improve pale complexion, but that it could also cure all nervous diseases, all female weaknesses, all diseases arising from mental worry, over-work, excess, early decay, etc., among many other conditions. Whenever any medical treatments claim to cure all of anything, it is a huge red flag that someone is over-promoting a product.

Other advertisements would describe someone (sometimes a child for maximal emotional impact) suffering from a severe medical condition who could not be saved by any other treatment except for these particular pills. Many advertisements contained the endorsement of a Reverend Enoch Hill, who claimed that the pills cured his headaches and gave him energy. The use of a holy man was not an accident because many people believed that such a person would not lie. Any testimonials or claims of miraculous recoveries were relied on heavily for advertising. Another trick that was used in the marketing was to create advertisements that were difficult to distinguish from genuine news articles.

In 1890, a Canadian physician, Dr. William Jackson, sold a Canadian businessman and politician named George Taylor Fulford the rights to Dr. Williams’ Pink Pills for Pale People. The Name “Pink Pills for Pale People” was merely a marketing technique used to draw attention to the product (by having four words start with the letter “P”). The rights were sold for $53.01 and would make Fulford a millionaire.

Also in 1890, John Mackenzie, a successful Canadian business man with journalism experience began to work for Fulford and helped publicize the pink pills. Beginning in 1900, the medication was sold by Dr. Williams Medicine Company, which was part of G. T. Fulford & Company. The latter was a company created by Fulford in 1887 to manufacture and distribute similar medications with extensive claims yet little to no evidence to back them up. Despite the lack of scientific evidence, Pink Pills for Pale People became very popular due to what it was claimed to accomplish and was sold in over 80 countries.

In reality, the main ingredient in Pink Pills for Pale People was iron. While the pills could have made some people with anemia feel better due to the iron content, they were much more expensive and did not contain as much iron as the regular iron pills prescribed by physicians. These pills did not require a prescription from a physician as they could be purchased from a pharmacist much like an over the counter medication is purchased today.

As you have probably figured out, Pink Pills for Pale People were not the cure-all they were claimed to be in public advertising. Ironically, only when someone bought the pills and received the official instructions did it say that the pills were not a cure-all (despite still saying in the instructions that the pills cured all conditions in numerous categories). Of course, the instructions say the only way a cure can be obtained is by taking more and more of the medication. One of my favorite sets of instructions had to do with men, which said that in order for the pills to work they needed to avoid lascivious thoughts, conversation, and books, “live a pure and manly life,” and follow many other directives. If one followed all of the instructions, it was said that a cure was sure to follow.

The reason that medications such as these and many other sham medications and treatments today have been successful for a time was because they offered hope for people in hopeless situations. Unfortunately, there will always be many people in such situations, which is why there will continue to be victims of these money-making schemes. Pink Pales for People, however, are no longer sold today. 

Lucky Strike, Marlene Dietrich, and Suspicious Scientific Claims

If you read my article entitled Five Ways to Evaluate Suspicious Medical Claims, you will see that Step 1 is to search the peer-reviewed medical literature. These days, it is easy to do, with online tools such as PubMed. Decades ago, however, it was not so easy and consumers largely had to rely on the honesty of the company making the claim, which is always a risky proposition because the company has a conflict of interest. A good example is this Lucky Strike cigarette ad in 1950 from actress and singer, Marlene Dietrich (click to enlarge).

Note how the ad days “Scientific tests prove Lucky Strike milder than any other principal brand!” What scientific test? Oh, the one confirmed by an “independent consulting laboratory.” While this ad was used decades ago, similar advertising techniques are still used today. So, if you see claims such as this, here are a few reasons to be skeptical:

1)    It’s a sales ad.
2)    There is no citation for the scientific research study in the advertisement (current scientific literature search shows no published scientific research on whether Lucky Strikes are truly milder).
3)    The supposed independent research lab is not named.
4)    Think creatively about how words can be played with. For example, the company owning Lucky Strike (American Tobacco) could have easily hired an independent consulting company (they don’t work for free) and paid them to “independently” confirm their research interpretations. After all, it does not technically say that the consulting lab ran its own tests. It only says that scientific tests were confirmed by the independent lab. The way the sentence is written leads you with the impression that separate studies were done. But, for all we know, American Tobacco just sent them their own lab results, had them look it over, and paid them to say that their claims were true without actually doing separate research studies.

The other thing to keep in mind, related to point #1, is that American Tobacco, the company that owned Lucky Strike was paying actors and actress huge sums of money for these types of endorsements, particularly for Lucky Strikes. The relationship was mutually beneficial. While American Tobacco benefited from a Hollywood endorsement, cigarette smoking was an essential part of Dietrich’s screen image.

Did You Know that Bayer Marketted & Sold Heroin?

While everyone reading this likely associates the name Bayer with aspirin, most people will be shocked to know that Bayer actually independently created, marketed, and sold heroin (as shown in the bottle above). That’s right…heroin, the highly addictive drug that is now illegal throughout the world. Below is the story of how this came to be and why it was stopped.

To take a step back, heroin was originally invented in 1874 by C.R. Alder Wright, an English chemist and physics researcher. When I say invented, that is because heroin does not occur naturally (unlike, say, marijuana) but needs to be synthesized. It is derived from combining morphine (a strong pain relieving substance) from the poppy plant with two acetyl groups (combinations of methane, carbon, and oxygen). This is why heroin is also known as diacetylmorphine. Wright was trying to a non-addictive alternative to morphine, which was frequently abused at the time and had undesirable side effects. 

In 1897, a chemist (Felix Hoffman) working at Bayer independently re-synthesized heroin under the supervision of his boss, Heinrich Dreser, who was the head of Bayer drug development. They were actually trying to produce codeine but heroin was the result. Still, the end result that is heroin has proven to be just as potent. Dreser tried it on himself and staff and enjoyed the effects it produced. In developing a marketing campaign, Bayer realized that calling it diacetylmorphine was not going to work. They needed a marketing name (trade name) and decided to call it Heroin. That’s right, Bayer came up with the name Heroin. It was so named because it had heroic effects on the user.

Bayer decided to market heroin it as a morphine substitute (to cure addictions to morphine) and cough suppressant (as you can see on the ad above, click to enlarge) from 1898 to 1910. Cough suppressants were important back then due to the problems caused by tuberculosis and pneumonia. Free samples were sent to thousands of doctors and by 1899 Bayer produced a ton of heroin a year (literally) and exported it to 23 countries. Back in those days, heroin was widely accepted as a legitimate medicinal drug, forms of it were available in drug stores, and the American Medical Association approved it in 1906 or 1907.

Despite Bayer’s hopes, it turned out that heroin was highly addictive, up to 4 times stronger than morphine, and rapidly metabolized into morphine once it crossed the blood-brain barrier. Basically, in trying to create an alternative to morphine that was less addictive, they created a faster acting version or morphine that was more addicting and caused rapid onset euphoria. Ooops. There began to be a very high demand for heroin by patients even though they were not in respiratory distress. A new group of addicts was created and numerous hospitalizations resulted. It was a historic embarrassment for Bayer and they ceased production of heroin in 1913 and removed it from their official company history. In case you were curious, the U.S. banned the manufacturing, sale, and importation of heroin in 1924.

A 39-Year Obesity Treatment Fraud

In 1900, the curious little advertisement below appeared in Cosmopolitan magazine that was addressed “To Fat People” (click to enlarge).

If you read my article entitled Five Ways to Evaluate Suspicious Medical Claims, you will see that this ad definitely met the criteria of seeming too good to be true. For example, losing 2 to 8 pounds a week without any radical change in what you eat and without any significant side effects?  You will also see that the weight loss treatment is pitched by someone who claims expertise in causing weight loss, a Dr. H.C. Bradford. He made the extreme guarantee that you will never feel better in your life if you try his treatment. In addition to weight loss, he claimed that problems in organs such as the heart, kidney, and stomach will be remedied. All you have to do is send away for a booklet.

As you can below (click to enlarge), these ads would continue and become even more dramatic, with pictures of “Fat People” who appeared sad and ashamed of themselves or of a thin woman who appeared the desired weight advertised “To Fleshy People.” It was a direct appeal to the emotions and struggles of people with obesity, to compel them to write in for the booklet and get them hooked. The ads below say much of the same as the original Cosmopolitan ad but add that the five-week system is perfected and based on scientific principles and common sense. Really? Even though you can “eat as much and as often as you please.” The claims came down to a 3 to 5 pound of weight loss per week. Another claim was that all patients would receive careful and personal attention whether treated by mail of in person. The name of the place to send information to even sounds pretty legitimate…The United States Medical Dispensary.

Curious, I decided to investigate further. All attempts to find out anything about the “United Stated Medical Dispensary” came up empty, which indicates to me that it was likely just a made up fancy-sounding name to impress potential customers. So then I turned my attention to Dr. H.C. Bradford. At first, all I could find were references to his advertising and nothing about the man. In fact, I have yet to find a copy of his pamphlet that he sent out to patients. If anyone has a copy (or can tell me more about H.C. Bradford), please let me know.

Finally, after continued research, I was able to locate an article from the Journal of the American Medical Association that shed light on the entire scam. The article is called “Bureau of Investigations: Bradford, Brough, Doyle, and Davis: Various Doctors Connected with Promotion of Obesity Cure.” You can read the entire article here, but if you do not care to, here is the summary.

As it turns out, H.Clark Bradford passed away in 1915 and his business was taken over by Dr. F. Thompson Brough. However, the technique sold was still referred to as The Bradford Method. Brough had already been known in the medical community as a quack. He committed suicide in 1930. The business was carried on by a Dr. Frank J. Doyle. After he died in 1939, the business was carried on by Dr. William A. Davis.

Bradford, Brough, and his successors had been selling patients pills with ingredients (e.g., baking soda, oil of peppermint, powdered rhubarb) that had nothing at all to do with weight reduction, were not scientifically proven, and actually could lead to harmful results. While the company claimed that no chemical preparations were used in their pills lab tests showed this was not true.

The Bradford Method was primarily a mail order business and the Post Office and American Medical Association began to investigate it due to concerns of mail fraud. The company continued to claim the specialized medical expertise was being brought to bear to treat obese patients but investigations found that Drs. Doyle and Davis had no such experience. Expert medical testimony showed that these doctors did not have enough information about their patients to prescribed safe, sure, or permanent obesity cures. It was found that The Bradford Method could actually lead to fatal reactions if certain other medical comorbidities were present.

Treatment was actually not individualized to the patient since all patients received the same medications for the first five weeks. Also, five weeks was just the beginning of a process that lured people into 45 weeks of medication use, massage lotion application, and exercises. Medical testimony showed that claims that patients would not be left with wrinkles, flabbiness, or other undesirable residuals were false as was the claim that the treatment with cure problems in the other organ systems. In fact, the ingredients in the pills were known to significantly irritate the gastrointestinal tract. The exercises prescribed were potentially dangerous in certain cases, yet this did not stop them from trying to sell the product to pregnant women.

When questioned under oath. Dr. David admitted he did not know much about metabolism and did not even know the basis used to determine a calorie. He claimed to be an expert on medications but could not answer basic some basic medication questions asked of him. He was forced to admit that many of the claims made in the advertisements were untrue. On 12/1/39, a fraud order was issued against the company, banning them from further use of the mail. And thankfully, that was the end of that, but many fraudulent medical claims and activities persist to this day which people need to be continuously on the look out for.

Natural Ways to Treat Mild Depression

At some point in life, mild depression affects everyone. Life is full of ups and downs and a person’s mood can be just as bumpy. Instead of drowning sorrows in pain-numbing methods such as excessive drinking, drug use or over-indulgence in food, there are healthy ways to actually trick the brain into being happy.


Here are five ways to boost your brain into creating more endorphins and thus create a feeling of natural happiness:

1. Daily Exercise

The immediate benefit of exercise is a better mood. Breaking a sweat literally clears the body and mind of toxins. In addition, mild physical exertion causes the brain to cope with this exertion by producing endorphins. Endorphins make us feel happy for the entire day.

2. Small Doses of Daily Sunshine

Small doses of sun have been scientifically proven to replenish the body of vitamin D. Vitamin D is known to improve mood and to support emotional well-being. Furthermore, the warmth of the sun causes the body to sweat. This sweat clears the body of toxins. The sun also emits infrared rays that heal various ailments and skin conditions.

3. Give Up Fried Foods

You certainly don’t have to give up fried foods forever. Just give them up until your mood improves. Then, eat fried foods sparingly. Fried foods deposit high levels of fat and grease in your body. Since the body and mind are connected, the mind is unhappy when the body is fed junk.

4. Make a Phone Call

Reaching out and connecting with another human being is healing. If a good friend isn’t available, contact a depression help online such as Depression Connect. When we suffer with mild depression alone, we live in our head and feed our own negative thoughts. Reaching out to another person will force you to take your attention off yourself and focus on someone else for a bit.

5. Help Someone Else

Force yourself to see how the other side lives. That is, spend time volunteering at a soup kitchen or any other charity that is in need of help. Seeing how hard other people have it can snap you out of any sad feeling you are entertaining.

If you are experiencing bouts of melancholy, take comfort and know that you are not alone. If you are having suicidal thoughts or your depression is not lifted by any of the above-mentioned methods, seek the help of a medical professional right away. You may be suffering with clinical depression or another treatable condition.

Note: The above entry is a guest blog entry.

Nervine: A Vintage Medication Pitched to Stressed Out Moms

Funny how now matter how much time passes, some themes never seem to change, such as the image of the stay-at-home mom stressed out by taking care of her children. So, in honor of Mother’s Day, here is a vintage medical ad (click to enlarge) for Nervine, which was indicated for anxiety, sleeplessness, or restlessness, complete with a money back guarantee. Nervine was available in liquid or effervescent form and it had a large female following.

Nervine was not only sold as a treatment for anxiety, sleeplessness, and restlessness but also for exhaustion, epilepsy (seizure disorder), spasms, fits, pain (including backache, headache, and nerve pain), depression, and St. Vitus dance. St. Vitus dance is a disease characterized by rapid, uncoordinated jerking movements mainly affecting the face, feet, and hands.

In the general sense, a “nervine” is a plant that has some type of positive effect on the nervous system. However, the active ingredient in Nervine was bromide (a form of bromine), which was once used as a sedative and an anti-convulsant (a medication used to treat seizures). While Nervine was claimed to be “…among the safest of effective medications to clam the nerves” this was not the case. The problem is that excess consumption of bromide can lead to bromism, which is a condition that leads to various psychiatric, neurological, gastrointenstinal, and dermatological symptoms.

Bromine and/or forms of bromine (e.g., bromides) are currently used in pesticides, disinfectants, flame retardants, as a gasoline additive, and for swimming pool maintenance. Its use has been limited in the U.S. but is still contained in some food products. Bromine has no known essential role in human health. The FDA does not currently approve bromine for the treatment of any disease and it was removed from all over the counter sedatives in 1975.

Nervine was the product of Dr. Franklin Miles, who started Dr. Miles Medical Company (which became Miles Laboratory in 1935) in Elkhart, Indiana. The company was in existence independently from 1885 to 1979, at which point it became a subsidiary of Bayer until 1995. The company achieved its initial success from Nervine, which led to a popular mail-order business and a free publication called Medical News which was really an advertising platform for the product. Nervine (which was often referred to as Dr. Miles Nervine) was taken off the market as a curative medication in the 1960s.

Cocaine Tooth Drops

Many people are aware that Coca-Cola used to contain a small amount of cocaine in the product but what many people may not know is that cocaine was widely used in many mainstream medical products back in the day, even for children. A good example is a real advertisement shown here for Cocaine Toothache Drops (click to enhance image).

The product claimed to produce and instant cure from toothache, which is probably correct since it has known anesthetic properties. The problem is that it can cause significant restriction of blood vessels, heart damage, and other negative effects throughout the body.

Cocaine Toothache Drops cost 15 cents when they were available (first registered in 1885; last sold in 1914). They were prepared by the Lloyd Manufacturing Co. in Albany, N.Y. and sold by pharmacists (known as druggists back then). No prescription was needed. Prior to 1914, cocaine was legal in the U.S.

In the times these drops were sold, cocaine was not considered harmful in moderate doses, which is a reminder of how commonly accepted medical advice today may some day be provided incorrect.

Junior Seau did NOT suffer 1500 concussions

In one of the most eye-catching headlines regarding the death of Junior Seau related to the pre-mature speculation that concussions caused him to commit suicide was the unfounded claim by a former teammate (Gary Plummer) that he suffered 1500 concussions (mild traumatic brain injuries) in a story run by USA Today. In the article, it states the following regarding Seau:

“If a 'Grade 1' concussion means you see stars after a hit, Plummer says he's had 1,000 in his career, and his ex-teammate, Junior Seau, had 1,500.”

The problem with this line of reasoning is that the premise is incorrect. Concussion grading scales were popularized by the American Academy of Neurology (AAN) in 1997. AAN described three grades of concussion, with higher grades reflecting a more significant injury. Grade 1 criteria are described as follows:

1.    Transient confusion.
2.    No loss of consciousness
3.    Concussion symptoms or mental status abnormalities on examination resolve in less than 15 minutes.

Grade 1 concussion is the most common yet the most difficult form to recognize. The athlete is not rendered unconscious and suffers only momentary confusion (e.g., inattention, poor concentration, inability to process information or sequence tasks) or mental status alterations. Players commonly refer to this stat as having been “dinged” or having their bell rung.”

There is nothing mentioned at all about seeing stars which is why Plummer’s premise is incorrect as are all of the subsequent calculations that lead to the 1500 concussion number. Alteration of mental status can refer to disorientation (e.g., not knowing where you are or what happened), post-traumatic amnesia, or retrograde amnesia, but not seeing stars. It can also refer to loss of consciousness, but loss of consciousness is not counted in Grade 1.

Seeing stars (technically known as photopsia) can technically caused by an infarctive (lack of oxygen) stroke in the occipital lobe (the visual processing area of the brain) but that is far different from a concussion. Most often, seeing stars is caused by mechanical stimulation of the nerves of the eye, which can occur after forces are applied to the head after a hit, but again, this is not the same as a brain injury.

You can easily cause the experience of seeing stars for benign reasons as well right now. Just take your two index fingers, gently press your eyelids when your eyes are closed, and you can see stars when your eyes are closed and even more so when they are open. Did you just give yourself a brain injury? Of course not. Certain medications (e.g., quetiapine, voriconazole) are known to cause photopsia. Other causes include retinal damage, ocular melanoma (cancer), and migraine headaches. When the retina is irritated, electrical impulses are discharged, which are interpreted by the brain as flashes of light (e.g., stars). It’s that simple.

To be fair to Plummer, he stated that he received his information from a concussion seminar in the 1990s, but if his recall of what he was told is accurate, then he was provided incorrect information.

Related Article: Does Second Impact Syndrome Exist?

Reference: AAN (1997). Practice parameter: The management of concussion in sports (summary statement), 48, 581-585.

Acne 101: A Primer

Causes of Acne
Acne is a condition that affects 20% of adults in the United States, approximately 60 million Americans. It affects all ages, races, and genders and, unfortunately, is one of the more stigmatized medical conditions, causing many people to experience significant depression and social alienation.

Additionally, treating acne can be a difficult, time-consuming ordeal and can sometimes still leave behind scars. Some sufferers seek acne scar treatment to erase the lesions left behind from bad cases of acne.

Most people associate acne with the hormones released during adolescence. While this is certainly a common source, it is not the only one. There are in fact, multiple causes for acne and each one may require a different treatment. Here are the 5 main causes of acne:

Hormones

Again, the most commonly associated cause of acne is the hormones released during adolescence. During puberty, male sex hormones create more androgen, which enlarges follicle glands and increases production of sebum. Other hormonal causes of acne include menopause, pregnancy and menstrual cycles.

Genes

Acne is not always genetic, but a predisposition to it can run in families. This predisposition can also make children more susceptible to acne lesions and scars.

Stress

Medical experts are still debating the role of stress in acne, but most agree that it does contribute to and, in some cases, cause acne. Many clinical studies have shown that high levels of stress (which are know to create hormonal imbalances) contribute to worsening acne conditions.

Infection

An anaerobic bacterium known as P. acnes causes acne, as does Staphylococcus epidermis. What is still unclear is whether these strains arise pathogenically or in relation to other adverse factors.

Diet

People often think that high sugar levels are what cause acne when really it is a matter of the glycemic load (GL) someone is consuming. The GL index determines how much a person’s blood glucose will rise. To be sure, foods with high sugar levels dominate the top of this list. Most commercial sodas and pastries contribute to worsening acne.

Treatment

Treatments for acne run the gamut from first line medications, antiseptics, antibiotics, hormones, topical retinoids, and anti-inflammatories to cosmetic procedures like dermabrasion, phototherapy light exposure, laser treatment and even surgery. People also try alternative medicines like egg oil, tea tree oil, and aloe vera. Natural treatments include dietary changes and exercise. Consult a doctor before pursuing any acne treatment.

Top Medical News: Obesity Epidemic, Dementia and Depression, Breast Cancer Detection & More

Rather than navigating to a variety of websites to stay on top of the top daily medical news, try bookmarking the MedFriendly Blog and using this feature, where the day's top medical stories are compiled all in one place.

1. Forty-two percent of US may be obese by 2030: study: Forty-two percent of the US population could be obese by 2030, up from about one-third currently, and the associated rise in health woes would likely cost $550 billion over two decades, said a study on Monday.

2. Depression in middle age linked to dementia: People who have symptoms of depression in middle age may be at increased risk of dementia decades later, a new study suggests.

3. Eating Well Without the Flavor of Shame: In his new book, the veteran food writer Peter Kaminsky writes that by maximizing flavor, you can satisfy your food cravings with smaller portions.

4. Is Workout Supplement Ingredient DMAA Safe?: Researcher Calls on FDA to Ban Speed-Like Ingredient DMAA.

5. Zinc Pills May Shorten Colds, Analysis Suggests: Those suffering from the common cold will try almost anything to relieve their symptoms, but a cure has yet to be found.

6. Curry Ingredient May Have Cancer Treatment Benefits: New research reveals that curcumin, found in the curry ingredient turmeric, may significantly reduce side effects for bowel cancer patients undergoing chemotherapy and help them to be able to go through treatment longer.

7. Idaho infant dies from whooping cough: Whooping cough took the life of a 9-week-old girl from Idaho this week, the first death from an outbreak of the highly contagious respiratory disease that has hit Idaho, Washington state and Montana, health officials said on Friday.

8. Mothers like chubby toddlers, study suggests: And nearly 70 percent unable to correctly assess their child's body size.

9. Range of brain diseases could be treated by single drug: The tantalising prospect of treating a range of brain diseases, such as Alzheimer's and Parkinson's, all with the same drug, has been raised by UK researchers.

10. Mammograms Beat Thermography for Breast Cancer Detection: Newer technology missed half of tumors and yielded many false positives, researchers say.

11. Greater Purpose in Life May Protect Against Harmful Changes in the Brain Associated With Alzheimer’s Disease: Greater purpose in life may help stave off the harmful effects of plaques and tangles associated with Alzheimer's disease, according to a new study by researchers at Rush University Medical Center.

12. Lab worker killed by rare bacteria was UC Berkeley grad who wanted to combat disease with science: A lab researcher apparently killed by the bacteria he was studying at the San Francisco VA Medical Center had dedicated himself to combating fatal diseases after a relative's death, said those who knew him.

13. Massive rise in Asian eye damage: Up to 90% of school leavers in major Asian cities are suffering from myopia - short-sightedness - a study suggests.

Top Medical News: Joggers Live Longer, Spouses and Dementia, Gym Mistakes, Meningitis Vaccine & More

Rather than navigating to a variety of websites to stay on top of the top daily medical news, try bookmarking the MedFriendly Blog and using this feature, where the day's top medical stories are compiled all in one place.

1. Joggers Live Much Longer: Results from the Copenhagen City Heart study reveals that regular jogging considerably increases life expectancy of men by 6.2 years and women by 5.6 years. In order to gain the optimum benefits for longevity the researchers recommend jogging at a slow or average pace for between one to two and half hours per week.

2. Bayer challenges India cancer drug ruling: German pharmaceutical giant Bayer AG has challenged a ground-breaking Indian ruling that allowed a local firm to produce a vastly cheaper copy of its patented drug for kidney and liver cancer.

3. Five Common Mistakes You’re Making at the Gym: Hitting the gym every day is great — unless you're doing it wrong. We've asked fitness experts to help tweak your workout to make it more effective.

4. When Illness Makes a Spouse a Stranger: Like many others, Ruth French finds herself grappling with her spouse’s frontotemporal dementia, a group of brain diseases that eat away at personality and language.

5. Multitasking Makes You Feel Good: Though Not Productive, Multitasking Fills Emotional Needs, Study Shows.

6. Germs Behind Urinary Tract Infections Becoming More Resistant to Drugs: E. coli bacteria’s resistance to ciprofloxacin (Cipro), the most widely prescribed antimicrobial for urinary tract infections in the United States, increased five-fold between 2000 and 2010, according to a new study.

7. Argentine 'miracle baby' tiny but stable a month on: An Argentine baby who was mistakenly declared dead and whose parents found her breathing in the morgue 12 hours later has survived her first month of life, weighing in at just under 1 kilo (2.2 pounds).

8. Early well-child check-ups can help identify children at risk of emotional, behavioral problems: A new study suggests clinicians might be able to identify children at risk of later emotional or behavioral problems by paying attention to a few key signs during early well-child check-ups.

9. Researchers closer to meningitis vaccine: Australian researchers say they are a step closer to developing a vaccine against the type of meningitis that mostly affects Europe and North America and kills hundreds every year.

Top Medical News: Can Email Kill You? Fertility Birth Defects, Breast Cancer Treatment, & More

Rather than navigating to a variety of websites to stay on top of the top daily medical news, try bookmarking the MedFriendly Blog and using this feature, where the day's top medical stories are compiled all in one place.

1. Taking E-Mail Vacations Can Reduce Stress, Study Says: You probably don’t need a doctor or scientist to tell you this, but your e-mail could be killing you.

2. Fertility treatment babies prone to 'serious defects': Children conceived with the aid of fertility treatments are more likely to be born with serious physical defects, according an Australian study published on Saturday.

3. Asthma an Often Unrecognized Risk for Older People: Study Shows That Older Adults With Asthma Often Face Serious Health Risks

4. Swaddling Infants Too Tightly May Cause Hip Problems: When swaddling an infant, make sure to leave the blankets loose enough to allow leg and hip movement, experts say.

5. Sports & Energy Drinks Damage Teeth: Sports drinks hit the wire today with a red light that their level of acidity is increasingly responsible for irreversible damage to teeth, especially amongst adolescents and younger adults, their predominant target market.

6. Recalled dog food tied to salmonella outbreak: At least 14 people in nine states have been sickened by a rare strain of salmonella linked to contaminated dry dog food, government health officials reported.

7. Squirrel tests positive for plague at California campsite: A ground squirrel trapped at a popular campground in southern California has tested positive for plague. 

8. Radiofrequency ablation during breast cancer surgery can provide effective alternative to XRT: Radiofrequency ablation of the lumpectomy site during breast cancer surgery can provide an effective alternative to post-operative external radiation therapy (XRT) and reduce repeat surgeries to achieve clear tumor margins, according to one of the first published long-term studies to examine this new treatment protocol.

9. Early Noninvasive Paternity Test Based on SNPs Is Accurate: A new test, based on single-nucleotide polymorphisms, that only requires a maternal blood sample can correctly identify paternity as early as 8 weeks' gestation, according to a letter published in the May 3 issue of the New England Journal of Medicine.

Top Medical News: Cheese Lowers BP, Bees Treat Prostate Cancer, Black Pepper Fights Fat, & More

Rather than navigating to a variety of websites to stay on top of the top daily medical news, try bookmarking the MedFriendly Blog and using this feature, where the day's top medical stories are compiled all in one place.
   
1. Cheese, please: Could a little Grana Padano drop your BP?: Integrating a type of Italian cheese, Grana Padano, into the usual diet of mildly hypertensive patients not taking any ACE inhibitors or angiotensin-receptor blockers (ARBs) resulted in a significant drop in mean blood pressure of 7 to 8 mm Hg compared with control patients, preliminary research shows.

2. Indian drug giant Cipla slashes cancer drug prices: Indian generic drug giant Cipla said Friday it had slashed by up to 76 percent prices of three anti-cancer medicines in what it called a "humanitarian" move and promised to cut the costs of more products.

3. Beastie Boy dead at 47: What is salivary gland cancer?: It's extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55.

4. Discrepancies on Medical Bills Can Leave a Credit Stain: As patients assume more of the responsibility for costs, complex billing and more aggressive collection by providers are resulting in negative credit report data that lingers for years.

5. Black Pepper May Help Fight Fat: Pungent Ingredient in Black Pepper Targets Fat Cells

6. Rising Obesity Rates Might Mean More Rheumatoid Arthritis: A new study suggests that severe weight gain might raise the risk for rheumatoid arthritis — a painful, chronic ailment — especially among obese women.

7. Nanotechnology In Medicine: Huge Potential, But What Are The Risks?: Nanotechnology promises to revolutionize drug delivery, gene therapy, diagnostics, and many areas of research, development and clinical application.

8. Amish farm kids remarkably immune to allergies-study: Amish children raised on rural farms in northern Indiana suffer from asthma and allergies less often even than Swiss farm kids, a group known to be relatively free from allergies, according to a new study.

9. Dental dilemma: Do kids need sealants?: Dental sealants are recommended for children when their permanent molars come in, but only a fraction of kids actually get them, say dentists who call the process one of the most under-used treatments to prevent decay in adult teeth.

10. Squirrel tests positive for plague at California campsite: A ground squirrel trapped at a popular campground in southern California has tested positive for plague.

11. Guidelines on cardiovascular disease prevention in clinical practice launched at EuroPRevent2012: The latest cardiovascular disease (CVD) prevention guidelines have been overhauled to produce a user friendly document with concise messages that awards greater weight than ever before to evidence from clinical trials and observational population studies.

12. FDA says study overestimated non-compliance with data-reporting laws: US drug regulator finds no evident harm caused by sponsors failing to post drug-trial data.

13. Beehive Extract Shows Potential as Prostate Cancer Treatment: An over-the-counter natural remedy derived from honeybee hives arrests the growth of prostate cancer cells and tumors in mice, according to a new paper from researchers at the University of Chicago Medicine.

CTE (Chronic Traumatic Encephalopathy) and Suicide Link is Premature Speculation

With the recent suicide of Junior Seau from an apparent self-inflicted gunshot wound to the chest, there is once again widespread speculation that the death was caused by possible chronic traumatic encephalopathy (CTE). CTE is a broad term used to refer to repetitive, often subclinical (e.g., asymptomatic), injury to the brain from a variety of contact sports and other causes. Whether or not Seau had this condition (his brain was just donated for scientific study to determine this), it is premature to speculate that he killed himself because of the condition.

Personally, I have never bought into the supposed link between CTE and suicide, as if people are mindlessly controlled to take their lives due to a distant history of concussions that may never have never been documented or known about. Are we to believe that Junior Seau seemed fine and jovial the week prior to his death and that CTE (which is a chronic condition) suddenly took control of his mind and caused him to shoot himself in the chest? That makes absolutely no sense whatsoever. Many of these player's had ample non-neurological explanations (e.g., business failings, federal indictments, depression about lack of post-career football success) for why they would commit suicide. I explain this more in an upcoming chapter on CTE that I wrote with Dr. Shane Bush:

Carone, D., Bush, S. (2012, in press). Dementia pugilistica and chronic traumatic encephalopathy. In R. Dean & C. Noggle (Eds.), Cortical Dementias.  New York:  Springer. 

In Seau’s case, we do not yet know what troubles he may have been experiencing in his life that led him to commit suicide and it is unclear if we will ever know since he did not leave a suicide note. But, the fact is that people kill themselves or try to kill themselves every day, even if they are perceived by others as successful in life. Many people put on a social mask to hide their inner distress from others and are unaware of the emotional distress that someone else may be experiencing. It is known Seau was divorced and was arrested in 2010 for history of domestic violence towards his ex-girlfriend. Hours later, he survived a 100-foot fall down a cliff in his SUV after he claimed he fell asleep. Perhaps, but it is also possible that this was an earlier suicide attempt in reaction to the events from hours earlier. The bottom line is that it is unclear if there was any family matters that could have contributed to his recent actions. 
For those who speculate that CTE caused Seau to commit suicide, it is important to note that suicide is an act that is completed or attempted by many professional and college athletes, including outside the NFL such as college basketball, professional basketball, college baseball, professional baseball, professional golf, and professional tennis players. Do all these athletes have CTE too? Are scientists hunting down their families to have them donate their brains for analysis? Not to my knowledge. Here is just a partial listing of many athletes who have killed themselves even if they didn't actually have a history of concussions or repetitive head trauma.

1. Thomas Emma (Duke basketball player)

http://rivals.yahoo.com/ncaa/basketball/blog/the_dagger/post/ex-duke-basketball-captain-dies-in-apparent-suicide-attempt?urn=ncaab,wp3264

2. Jim Dinwiddie (Kentucky basketball player)

http://www.kentucky.com/2012/02/07/2059865/former-uk-wildcat-basketball-player.html

3. Mel Turpin (Kentucky basketball player)

http://bleacherreport.com/articles/417496-mel-turpin-80s-basketball-star-commits-suicide

4. Troy Raymond (NBA and college basketball player):

http://probasketballtalk.nbcsports.com/2011/08/16/former-nba-current-college-referee-commits-suicide/

5. Nine other basketball players:

http://en.wikipedia.org/wiki/Category:Basketball_players_who_committed_suicide

6. Erica Blasberg (professional golfer)

http://www.cbsnews.com/8301-504083_162-20014634-504083.html

7. Mike Flanagan (MLB player)

http://articles.nydailynews.com/2011-08-25/sports/29951521_1_flanny-mike-flanagan-orioles-owner-peter-angelos

8. Hideki Irabu (MLB player)

http://keepingscore.blogs.time.com/2011/07/29/hideki-irabu-a-one-time-baseball-sensation-meets-a-sad-end/

9. Stephan Gant (top MLB prospect)

http://msn.foxsports.com/mlb/story/vanderbilt-baseball-signee-mlb-draft-prospect-stephen-gant-dies-apparent-suicide-040412

10. Jennifer Capriati (professional tennis player, attempted suicide)

http://www.dailymail.co.uk/news/article-1290590/Jennifer-Capriati-attempted-suicide-depression-failed-tennis-career.html

Also see the entries entitled, Junior Seau did NOT suffer 1500 concussions and Does Second Impact Syndrome Exist?  \