Five Ways to Evaluate Suspicious Medical Treatment Claims

There has never been a shortage of people proposing miracle medical cures for various ailments, conditions, and diseases. In the 19th century, women would line up to buy vegetable compounds to treat hormonal symptoms, people would buy swamp roots to treat kidney problems, and hippopotamus fat was used as an ingredient to treat baldness.

Medical compounds with questionable effectiveness were known as nostrums or patent medications, even though most were never actually patented. Some patent medications actually worked but had toxic/negative side effects, such as slow death from mercury poisoning when mercury was used treat syphilis or addiction from treating colicky infants with opium. After 100 people died from a drug tainted with an untested solvent in 1937 (known as the Elixir Sulfanilamide tragedy), Franklin Roosevelt signed the Food, Drug, and Cosmetic Act, which increased regulation over medication, required pre-market testing of all new drugs, and banned false therapeutic claims in drug labeling.

These days, suspicious claims of supposed miracle medical cures still exist. The people most vulnerable to trying these treatments are those who are faced with an incurable disease that modern conventional medicine cannot effectively treat or those who have not responded to curable diseases via conventional medicine.

These supposed treatments can now be easily discovered with a quick internet search, but how are consumers supposed to evaluate their effectiveness and how should healthcare providers respond to patient questions about these treatments? Below I will offer some tips on how to do this by using a modern example: the claim that Alzheimer’s disease can be effectively treated or reversed by using coconut oil. This is based on the theory that coconut oil will provide the brain with an alternative source of energy (ketones) due to an impaired ability to use its usual energy source (glucose).

STEP 1: SEARCH THE PEER-REVIEWED MEDICAL LITERATURE: The best place to search the medical literature for peer reviewed scientific research is PubMed. All searches are free, most results contain a summary of the findings, an option to read the entire article (for free or purchase), and contact information for the authors to request a copy of the article. Peer-review acts as a quality control. Articles that have not been peer-reviewed and are merely published on a blog or a website only, have less credibility because they lack peer review. There are no articles on PubMed researching coconut oil as a treatment for Alzheimer’s disease. However, there was an article published by Granholm and colleagues in 2008 showing that a diet high in hydrogenated coconut oil (which contains harmful transfats not found in organic coconut oil) in rats can profoundly impair memory and the structure of the hippocampus (the main part in the brain responsible for memory). Strike 1 against coconut oil, at least the hydrogenated type. See the articles on Lucky Strike cigarettes and Oxydendrine for another discussion of the importance of Step 1.

STEP 2: EVALUATE THE QUALITY OF PEER REVIEWED RESEARCH: Although peer reviewed research is generally higher quality than non-peer reviewed research, there are many peer reviewed articles than contain significant design flaws, limiting the conclusions that can be drawn. The best research evidence comes from studies in which patients were randomly assigned to treatment groups, in which neither the treater or patient are aware of the specific treatment (this is known as being double-blind), and in which one of the treatments was a placebo (a substance containing no actual medication). The less the study contains these features, the less confidence you should have in the results. 

STEP 3: RESEARCH WHO IS PROMOTING THE TREATMENT: It is important to evaluate the person or group of people promoting the supposed treatment to determine if there are reasons to cause suspicion about the accuracy of the claims being made. Examples can include a financial conflict of interest, desire to help a loved one with the proposed treatment, or anger towards conventional medicine. Coconut oil treatment for Alzheimer’s is mainly promoted by a single person (a physician) whose husband has Alzheimer’s disease. This doctor is selling a book based on the claim and has published comments on a website taking personal credit for outsmarting drug companies along with apparent antipathy towards those companies that make “monopoly profits.” This is not to say that family of sick loved ones cannot come up with useful treatments for uncurable conditions. In fact, Augusto and Micheala Odone did exactly that when they discovered that very long chain fatty acids from rapeseed and olive oil can treat adrenoleokodystrophy (a rare and deadly genetic metabolic disorder). The difference, though, is that there is peer reviewed research to support this treatment. Overall, strike 2 against coconut oil.

STEP 4: BE SKEPTICAL OF SUSPICIOUS CLAIMS: As a general rule, if it sounds too good to be true, it usually is. One example is a claim that you can cure obesity by allowing people to eat whatever they want, such as in this 39-Year-Old Obesity Fraud. Or, claims that the treatment can cure just about anything such as Pink Pills for Pale People, the Electric Chain Belt or The Tapeworm Diet. Another good example is a claim that an incurable disease can be cured with the proposed treatment. The fact is that Alzheimer’s disease is incurable and causes progressive degeneration of brain tissue, yet the claim is being made that coconut oil can reverse Alzheimer’s disease and totally halt brain atrophy. These claims are partly based on the doctor observing changes in her husband after using the coconut oil, which leads to a subjective investment in believing the treatment will work. This is not the standard by which medication effectiveness is judged and is very far from the randomized, double-blind, placebo controlled studies mentioned above. Strike 3 against coconut oil.  

STEP 5: RESEARCH WHAT RESPECTABLE ORGANIZATIONS DEVOTED TO THE CONDITION SAY ABOUT THE TREATMENT: If the supposed treatment is not mentioned on professional organizational websites or medical literature devoted to the condition, that is reason to be suspicious. If the treatment is mentioned and discredited, this is even further reason for suspicion. Here is some of what the Alzheimer’s Association says about coconut oil treatment: "A few people have reported that coconut oil helped the person with Alzheimer’s, but there’s never been any clinical testing of coconut oil for Alzheimer’s, and there’s no scientific evidence that it helps." Coconut oil is an ingredient in a medical food marketed for Alzheimer's disease known as Axona, but the official position of the Alzheimer’s Association is that there is no evidence that medical foods help treat this condition. Strike 4 against coconut oil.

In the end, always be cautious and skeptical and be careful about what home remedies you use to treat a loved one, because you may actually cause more harm than good.

Suggested reading: A Brief History of Bad Medicine